REAGENT or RESOURCE	SOURCE	IDENTIFIER
P. falciparum Strains
W2	Malaria Research and Reference Reagent Resource Center (MR4)	MRA-157
Dd2attB	Malaria Research and Reference Reagent Resource Center (MR4)	MRA-843
019313R1	This paper.	n/a
019313R2	This paper.	n/a
RL2-FPPS/GGPPS-GFP	This paper.	n/a
RL2-FPPS/GGPPS(S228T)-GFP	This paper.	n/a
CaM-FPPS/GGPPS-GFP	This paper.	n/a
CaM-FPPS/GGPPS(S228T)-GFP	This paper.	n/a
Bacterial Strains
Stellar Chemically Competent Cells	Clonetech	636766
One shot BL21 Star (DE3) Chemically Competent	ThermoFisher	C601003
Chemicals
Malaria Box Compound library	Medicines for Malaria Venture	n/a
MMV019313	ChemDiv	C498-0579
ISOPENTENYL PYROPHOSPHATE, NH4+ SALT	Isoprenoids, ltd.	IPP001
GERANYL PYROPHOSPHATE, NH4+	Isoprenoids, ltd.	GPP002
E,E-FARNESYL PYROPHOSPHATE, NH4+	Isoprenoids, ltd.	FPP003
Recombinant Proteins
PfFPPS/GGPPS	This paper.	n/a
PfFPPS/GGPPS(S228 T)	This paper.	n/a
HsFPPS	This paper.	n/a
HsGGPPS	This paper.	n/a
Recombinant plasmid DNA
pET28-PfFPPS/GGPPS	This paper.	n/a
pET28-PfFPPS/GGPPS(S228 T)	This paper.	n/a
pET28-HsGGPPS	This paper.	n/a
pET28-HsFPPS	This paper.	n/a
pLN(RL2)-PfFPPS/GGPPS-GFP	This paper.	n/a
pLN(RL2)-PfFPPS/GGPPS(S228 T)-GFP	This paper.	n/a
pLN(CaM)-PfFPPS/GGPPS-GFP	This paper.	n/a
pLN(CaM)-PfFPPS/GGPPS(S228 T)-GFP	This paper.	n/a
Antibodies
αGFP mouse monoclonal, JL-8	Clonetech	632381
Critical Commercial Assays or Reagents
PPiLight Inorganic Pyrophosphate Assay	ThermoFisher (Lonza)	NC0665609
Talon Metal Affinity Resin	ThermoFisher (Clonetech)	NC9484031
Deposited Data
Whole genome sequencing data	This paper. NCBI SRA# SRP106479	https://www.ncbi.nlm.nih.gov/sra
Software
BD Accuri C6 Software, version 1	BD Biosciences	https://www.bdbiosciences.com/us/instruments/research/cell-analyzers/bd-accuri/m/1294932/features/software
Excel for Mac, version 15.33	Microsoft Office	https://products.office.com/en-us/excel
Prism, version 7	GraphPad	https://www.graphpad.com
Maestro, Small-molecule drug discovery suite, release 2017-1	Schrödinger	https://www.schrodinger.com/suites/small-molecule-drug-discovery-suite