Table 2. The criteria and the level of evidence for assessing drug-induced thrombocytopenia.
Criteria # | Criteria consideration | ||
1 | Therapy with the suspected drug was instituted prior to the development of thrombocytopenia and the resolution of thrombocytopenia occurred after the discontinuation of the suspected drug | ||
2 | Only the suspected drug was used before the onset of thrombocytopenia and the platelet count was normal or continued to rise toward normal range with continuation or reinstitution of other drugs after the suspected drug was discontinued | ||
3 | Other causes for thrombocytopenia were excluded | ||
4 | The suspected drug resulted in the recurrent thrombocytopenia on re-challenge or re-exposure | ||
Level of evidence | Criteria met | Remark | |
I | 1, 2, 3 and 4 | The suspected drug is a definite cause | |
II | 1, 2 and 3 | The suspected drug is a probable cause | |
III | 1 only | The suspected drug is a possible cause | |
IV | 1 is absent | The suspected drug is unlikely to be a cause |