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. Author manuscript; available in PMC: 2018 Feb 20.
Published in final edited form as: Pigment Cell Melanoma Res. 2017 Jun 8;30(4):428–435. doi: 10.1111/pcmr.12591

Figure 1. Generation and Characterization of YUMMER1.7.

Figure 1

(A) YUMMER1.7 was generated from YUMM1.7 using three rounds of UVB radiation and a single cell-derived clone was expanded.

(B) Total point mutations in YUMMER1.7 compared to YUMM1.7 categorized based on the type of base substitution.

(C) Growth of 100,000 cell YUMM1.7 and YUMMER1.7 tumors engrafted into wild-type C57BL/6J mice.

(D) Growth of 100,000, 250,000, 500,000, and 1,000,000 cell YUMMER1.7 tumors engrafted into wild-type C57BL/6J mice.

(E) Growth of 100,000 cell YUMM1.7 tumors and YUMMER1.7 tumors engrafted into Rag1−/− C57BL/6J mice.

(F) Growth of 100,000 cell YUMMER1.7 tumors engrafted into wild-type C57BL/6J mice that were treated with depleting antibodies against CD4, CD8 or both.

Tumor growth curves are representative of two independent experiments (mean ± SEM, n = 5 each).