(A) YUMMER1.7 was generated from YUMM1.7 using three rounds of UVB radiation and a single cell-derived clone was expanded.
(B) Total point mutations in YUMMER1.7 compared to YUMM1.7 categorized based on the type of base substitution.
(C) Growth of 100,000 cell YUMM1.7 and YUMMER1.7 tumors engrafted into wild-type C57BL/6J mice.
(D) Growth of 100,000, 250,000, 500,000, and 1,000,000 cell YUMMER1.7 tumors engrafted into wild-type C57BL/6J mice.
(E) Growth of 100,000 cell YUMM1.7 tumors and YUMMER1.7 tumors engrafted into Rag1−/− C57BL/6J mice.
(F) Growth of 100,000 cell YUMMER1.7 tumors engrafted into wild-type C57BL/6J mice that were treated with depleting antibodies against CD4, CD8 or both.
Tumor growth curves are representative of two independent experiments (mean ± SEM, n = 5 each).