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. Author manuscript; available in PMC: 2019 Mar 1.
Published in final edited form as: J Diabetes Complications. 2018 Jan 3;32(3):330–334. doi: 10.1016/j.jdiacomp.2017.12.012

Table 2.

Associations between the genetic risk scores and cardiometabolic risk factors

Variable GRS-D
GRS-I
GRS-ALL
Beta (SE) P Beta (SE) P Beta (SE) P
BMI 0.02 (0.05) 0.74 0.24 (0.04) 2.67×10−8 0.10 (0.03) 6.14 ×10−5
WHR 0.0003 (0.001) 0.68 0.002 (0.001) 0.001 0.001 (0.0004) 0.04
Insulin −1.37 (0.56) 0.01 0.57 (0.51) 0.26 −0.19 (0.30) 0.53
Insulin* −1.36 (0.48) 0.005 −0.77 (0.44) 0.08 −0.74 (0.26) 0.005
HOMA-IR −0.05 (0.02) 0.02 0.02 (0.02) 0.26 −0.01 (0.01) 0.60
HOMA-IR* −0.05 (0.02) 0.01 −0.03 (0.02) 0.08 −0.03 (0.01) 0.009

BMI=body mass index; GRS-ALL=genetic risk score including all 12 variants for body fat percentage; GRS-D=genetic risk score including three body fat percentage variants associated with decreased type 2 diabetes risk; GRS-I=genetic risk score including five body fat percentage variants associated with increased type 2 diabetes risk; HOMA-IR=homeostatic model assessment for of insulin resistance; WHR=waist-hip ratio

P values were adjusted for age, sex, smoking, and drinking.

*

additionally adjusted for body mass index.