. Author manuscript; available in PMC: 2019 Mar 1.

Published in final edited form as: J Diabetes Complications. 2018 Jan 3;32(3):330–334. doi: 10.1016/j.jdiacomp.2017.12.012

Table 3.

Odds Ratio of type 2 diabetes associated with per SD change in genetic risk scores for body fat percentage.

Models^*	GRS-D		GRS-I		GRS-ALL
Models^*	OR (95% CI)	P	OR (95% CI)	P	OR (95% CI)	P
Model 1	0.96 (0.86 - 1.07)	0.45	1.17 (1.06 - 1.30)	0.002	1.04 (0.99 - 1.11)	0.14
Model 2	0.95 (0.85 - 1.06)	0.38	1.13 (1.02 - 1.25)	0.02	1.03 (0.97 - 1.09)	0.32
Model 3	0.95 (0.84 - 1.06)	0.35	1.16 (1.04 - 1.29)	0.008	1.04 (0.98 - 1.11)	0.23

GRS-ALL=genetic risk score for all body fat percentage loci; GRS-D=genetic risk score for body fat percentage loci decreasing type 2 diabetes risk; GRS-I= genetic risk score for body fat percentage loci increasing type 2 diabetes risk

Covariates included in the three models:

Model 1: Age, sex, smoking, and drinking;

Model 2: variables in model 1 plus body mass index;

Model 3: variables in model 2 plus education, physical activity index, energy intake from dietary and ethanol consumption, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and triglycerides