Table 1.
Deregulated miRNAs and target genes by acetaminophen exposure
| miRNA name | FCsa | Target genesb |
|---|---|---|
| hsa-miR-10b-5p | 2.306 | ALPL, ANXA13, BDH1, CHST4, ECM2, ETNK2, IYD, MTMR3, SDPR, SLC10A1, VNN1 |
| hsa-miR-122-5p | 0.201 | GPR1, MAFF, NCAM1, RGS16, SESN2, SLC7A11, SLC7A5, SLC9A1, SLCO5A1 |
| hsa-miR-1246 | 5.994 | HMGCS2 |
| hsa-miR-1268a | 0.458 | MAFF, SLC6A9, UNC5B |
| hsa-miR-128-1-5p | 0.469 | CPA4, DCLK1, HFE, ICOSLG, NCAM1, NGFR, SLC1A4, SLC6A17, SLC7A11, SLC7A5, TPRXL, TPRXL, ASNS |
| hsa-miR-1290 | 2.520 | HNMT, MTMR3, PLGLB2 |
| hsa-miR-129-5p | 2.156 | ABCA6, MTTP, PIPOX |
| hsa-miR-130b-5p | 0.335 | MAFF, SESN2, SLC7A11, UPP2 |
| hsa-miR-139-5p | 3.133 | ALDH1A1, CDH1, HNMT, MYLK, SERPIND1, ST6GAL1, TNFSF10 |
| hsa-miR-143-3p | 2.234 | MASP1 |
| hsa-miR-181d-5p | 2.049 | ACSS1, AQP9, IYD, KCNK5, SLC5A9 |
| hsa-miR-185-5p | 0.421 | CPA4, HCN4, HFE, NCAM1, RGS16, SESN2, SLCO5A1, SYP |
| hsa-miR-192-3p | 0.448 | DUSP5, ICOSLG |
| hsa-miR-192-5p | 0.465 | ARL4C, ATF3, NGFR, PSAT1 |
| hsa-miR-194-3p | 0.297 | ARHGEF2, ARL4C, FOSL1, HAP1, ICOSLG, MAFF, NCAM1, NGFR, RFX2, SERPINE1, SLC1A4, SLC6A17, SLC7A5 |
| hsa-miR-199a-3p | 2.103 | PLGLB2, SGK2 |
| hsa-miR-210-5p | 0.316 | HCN4, IGFBP3, NCAM1, NGFR |
| hsa-miR-224-5p | 3.737 | CDH1, CYP3A4, DIO1, IFITM2, KLHDC7A, MTMR3, OLFML3, SDS, SLC47A2 |
| hsa-miR-3065-5p | 3.564 | DDC, ECM2 |
| hsa-miR-30b-3p | 0.320 | ARL4C, CPA4, HAP1, MAFF, NGFR, SLC7A5, SYP, TNFRSF9, UNC5B |
| hsa-miR-3144-3p | 2.933 | SORBS2, UGT2A3 |
| hsa-miR-320a | 2.481 | C6, CYP8B1, DDC, EDN2, FYN, HNF1A, HOXA3, MAP2K6, MTMR3, NQO1, RCN3, RORC, SELL, SLC17A4, SORBS2, TM4SF4 |
| hsa-miR-320b | 6.750 | C6, CYP8B1, DDC, EDN2, FYN, HNF1A, HOXA3, MAP2K6, MTMR3, NQO1, RCN3, RORC, SELL, SLC17A4, TM4SF4 |
| hsa-miR-320c | 7.557 | C6, CYP8B1, DDC, EDN2, FYN, HNF1A, HOXA3, MAP2K6, NQO1, RCN3, RORC, SELL, SLC17A4, TM4SF4 |
| hsa-miR-320d | 10.65 | C6, CYP8B1, EDN2, HOXA3, MAP2K6, NQO1, RCN3, RORC, SELL, TM4SF4 |
| hsa-miR-33b-3p | 0.358 | ARL4C, SLC6A17, UPP2 |
| hsa-miR-449a | 2.586 | CEACAM1, ESPN, FETUB, GBA3, HNF4A, IYD, KRT5, MASP1, NQO1, NRXN2, TM4SF4 |
| hsa-miR-877-5p | 2.120 | AQP9, CYP1A1, G6PC, MASP1, MAT1A, NR1I2, OLFML3 |
| hsa-miR-92b-3p | 0.482 | SLC9A1 |
a
Fold changes of miRNAs in HepaRG cells treated by 10 mM acetaminophen
b
Predicted by IPA software