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. Author manuscript; available in PMC: 2019 Mar 1.
Published in final edited form as: J Intern Med. 2018 Feb 19;283(3):218–237. doi: 10.1111/joim.12732

Figure 1.

Figure 1

Multiple different proteins are associated with amyloid disease and form deposits in various organs. Each form of amyloidosis is defined by the molecular identity of the amyloid fibril protein that deposits and gives rise to the disease condition. The figure illustrates the proteins discussed in this article and the main organs affected by the respective protein. Aβ, Tau, α-syn, and PrP in brain, SAA in kidney, spleen, and liver. IgG light chains are found in most tissues except for the CNS but mainly in kidney, heart, and liver. TTR in heart, peripheral nerves, eye and CNS.