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. Author manuscript; available in PMC: 2019 Mar 1.
Published in final edited form as: J Intern Med. 2018 Feb 19;283(3):218–237. doi: 10.1111/joim.12732

Figure 8.

Figure 8

HET-s as a high resolution amyloid target testbed for amyloid probes. A. Structural model of HET-s (218–289) monofilament in complex with the LCO p-FTAA overlapping with the Congo red binding site. Pdb code 2MUS was used to create the structure in PyMol. B. Hypothetical trimeric HET-s filament where the BS2 site is retained and a novel binding site (BS1) suggestively forms at the filament interface. PDB: 2RNA [21, 45, 109]. Note: The BS2 and BS1 nomenclature comes from the Lockhart binding site model proposed for Aβ fibrils [110].