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Tau ligands distinguish between tau pathologies in different diseases.
| Ligand | Tau | ||||
|---|---|---|---|---|---|
| AD | PSP | FTD | CBD | P301S (mouse) | |
| Congo Red | + | + | + | + | + |
| FDDNP | + | + | − | − | − |
| T807* (AV-1451) | + | − | − | − | − |
| THK-523* | + | − | − | − | − |
| PBB3 | + | + | + | + | + |
AD = Alzheimer’s disease; PSP = progressive supranuclear palsy; FTD = frontotemporal dementia; CBD = corticobasal degeneration; P301S = tau P301S mutant expressed in a tg-mouse model of FTD/CBD.
T807 and THK-523 bind to distinct sites on tau.
