Table 4.

Clinical and immunological factors associated with graft loss (Univariate Analysis).

Variable	Hazard ratio (95% CI)	p value
Donor age-yr.	1.0 (0.96–1.05)	0.97
Donor gender (male)	0.35 (0.16–0.76)	0.009
Ischemic time-min	0.99 (0.99–1.01)	0.76
Age at HT-yr.	1.01 (0.94–1.07)	0.86
Recipient gender (male)	1.05 (0.51–2.16)	0.89
Pre-HT diagnosis-CHD	2.05 (0.99–4.24)	0.051
Previous cardiac surgery	2.18 (1.05–4.51)	0.034
Pre-HT PRA ≥10%	1.41 (0.62–3.20)	0.41
Number of acute rejections/patient-year	1.43 (1.1–1.8)	0.026
Steroid off at 1-yr post-HT	0.32 (0.13–0.76)	0.001
VAD use	0.3 (0.07–1.30)	0.27
Inotropes at HT	0.46 (0.06–3.46)	0.45
Ventilator at HT	2.84 (1.32–6.13)	0.007
Renal insufficiency	3.52 (1.53–8.08)	0.0029
Albumin	0.88 (0.47–1.66)	0.71
Bilirubin	1.07 (0.89–1.30)	0.42
HLA mismatch	0.86 (0.69–1.07)	0.18
Class I DSA	0.00 (0.0000)	0.99
Class II DSA	0.6 (0.24–1.50)	0.28
Class I and II DSA	1.88 (0.87–4.05)	0.10
DSA MFI (log-transformed)	1.02 (0.57–1.84)	0.94
C1q+ DSA	1.4 (0.65–3.00)	0.19
C1q− DSA	0.37 (0.08–1.65)	0.19
Era of transplant (2006–2010)	1.28 (0.50–3.29)	0.59
Era of transplant (2011–2014)	0.32 (0.07–1.34)	0.11