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. Author manuscript; available in PMC: 2019 Mar 15.
Published in final edited form as: Neuropharmacology. 2017 Nov 3;131:200–208. doi: 10.1016/j.neuropharm.2017.10.040

Figure 2.

Figure 2

Effect of AM4113 on ethanol consumption and preference was examined using a two-bottle choice paradigm. AM4113 significantly suppressed ethanol consumption at dose 1 mg/kg on day 1 (***p<0.0001) and 2 (*p<0.05), and at dose 3 mg/kg on day 1 (***p<0.0001), day 2(***p<0.0001), day 3 (*p<0.05) and day 4 (*p<0.05). A marked reduction in ethanol preference was observed at dose 1 mg/kg on day 1 (***p<0.0001) and 2 (*p<0.05), and at dose 3 mg/kg on day 1 (***p<0.0001), day 2 (***p<0.0001), day 3 (*p<0.05) and day 4 (*p<0.05). Data are presented as mean ± SEM. (p values are relative to the vehicle treated group (Vehicle = 10; 1 mg/kg =10; 3 mg/kg = 11); Two-way mixed ANOVA with Bonferroni post-hoc test).