Skip to main content
. Author manuscript; available in PMC: 2019 Mar 15.
Published in final edited form as: Neuropharmacology. 2017 Nov 3;131:200–208. doi: 10.1016/j.neuropharm.2017.10.040

Figure 4.

Figure 4

Microdialysis studies were conducted to examine the effect of AM4113 on ethanol-induced on dopamine (DA) release in nucleus accumbens shell (NAcS). Ethanol (1.5 g/kg, i.p.) was administered 120 min after the injections of either vehicle (n=5) or AM4113 (1 mg/kg, i.p.; n=8). Ethanol significantly increased DA release at 20 min (**p<0.001), 40 min (***p<0.0001) and 60 min (*p<0.05) post-injections compared to vehicle treated group (A). Ethanol-induced DA level was suppressed by AM4113 treatment after 40 min of ethanol injection (#p=0.0012; A). The placements of microdialysis probes were verified histologically. A representative image with arrow indicate a probe placement in NAcS (B). Data are presented as mean ± SEM.