Effect of AM4113 treatment on ethanol metabolism. Blood ethanol concentration (BEC) was measured at 40, 80 and 120 min following ethanol administration (1.5 g/kg., i.p.). There was a significant effect of time on BEC [F(2,24) =2 21.9; p<0.0001]. However, no significant effects of either AM4113 treatment [F(2,12) = 0.17; p = 0.84] or interaction between time and AM4113 treatment [F(4,24)= 0.80; p = 0.53] were observed compared to vehicle treated group. Data are presented as mean ± SEM (n = 5 per group).