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. Author manuscript; available in PMC: 2019 Mar 1.
Published in final edited form as: Proteins. 2017 Oct 16;86(Suppl 1):27–50. doi: 10.1002/prot.25392

Figure 6. The structure of WWAV-GP1 compared to the top three models.

Figure 6

(A): Ribbon diagrams of the WWAV-GP1 colored in rainbow and shown in a putative complex with hTfR1 (surface representation) (PDB ID: 3KAS). (B): A potential charge-repulsion between two negatively charged groups on WWAV and hTfR1 that was identified using this analysis. (C): Comparison of the top three models from ‘MULTICOM-construct’, ‘MULTICOM-novel’, and ‘GOAL’ (designated S236, S345, and S220, respectively) with WWAV-GP1. (D): A close-up view comparing the loops of WWAV-GP1 that interact with hTfR1 to the top model. Structures were rendered using PyMOL (www.pymol.org).