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. Author manuscript; available in PMC: 2019 Mar 1.
Published in final edited form as: Anesth Analg. 2018 Mar;126(3):867–875. doi: 10.1213/ANE.0000000000002646

Table 1.

Baseline Characteristics of Included Studies

Study
(Reference)
(IH or
PH/NT)		 Presenting
Rhythm		 Method of
Cooling		 Duration
of
Cooling		 Time That
Cooling Was
Commenced		 Target
Temperature
(Degrees
Celsius)		 Follow-Up
Period		 ROSC
(Time in
Minutes)
(TTM/NT)		 Age
(Years)
(TTM/NT)		 Male (%)
(TTM/NT)		 Patients
Receiving
Bystander
CPR (%)
(IH or
PH/NT)
Bernard et al 20022 (N=43 PH/34 NT) VF Ice packs 12 hours After ROSC 33° Till discharge 27/25 67/65 58/79 49/71
Holzer et al 20023 (N=137 IH/138 NT) VF/Pulseless VT External cooling device 24 hours After ROSC 32–34° 6 months 21/22 59/59 77/75 49/43
Hachimi-Idrissi et al 200518 (N=30 IH/31 NT) Asystole/PEA and VF/Pulseless VT Cooling helmet Up to 24 hours After ROSC 33° 6 months 29/28 67/69 77/68 30/26
Kämäräinen et al 200923 (N=19 IH/18 NT) Asystole/PEA and VF/Pulseless VT Coooled intravenous fluid infusion - After ROSC 33° Till discharge 23/22 59/63 95/94 58/22
Nielsen et al 20135 (N=473 IH/466 NT) Asystole/PEA and VF/Pulseless VT Ice packs and cooled intravenous fluid infusion 28 hours After ROSC 33° 8.5 months 25/25 64/64 83/79 73/73
Study
(PH/IH)		 Presenting
Rhythm		 Method of
Cooling		 Duration
of
Cooling		 Time That
Cooling Was
Commenced		 Target
Temperature
(Degrees
Celsius)		 Follow-Up
Period		 ROSC
(Time in
Minutes)
(PH/IH)		 Age
(Years)
(PH/IH)		 Male (%)
(PH/IH)		 Patients
Receiving
Bystander
CPR (%)
(PH/IH)
Castrén et al 201019 (N=93/101) Asystole/PEA and VF/Pulseless VT Transnasal evaporative cooling then systemic cooling - Intra-arrest 34° 7 days 32/30 66/64 67/79 33/46
Bernard et al 201020 (N=118/116) VF Cooled intravenous fluid infusion 24 hours After ROSC 33° Till discharge 26/26 63/63 83/86 69/67
Bernard et al 201221 (N=82/81) Asystole/PEA Surface cooling using machines, blankets, and ice packs; cooled intravenous fluid infusion 24 hours After ROSC 32–34° Till discharge 29/29 64/61 57/48 36/31
Debaty et al 201425 (N=123/122) Asystole/PEA and VF/Pulseless VT Cooled intravenous fluid infusion and external cooling 24 hours Intra-arrest 32–34° 12 months 27/30 66/69 72/71 50/52
Maynard et al 201524 (N=688/671) Asystole/PEA and VF Cooled intravenous fluid infusion Up to 24 hours After ROSC 34° 12 months for mortality outcomes and three months for neurological outcomes 27/26 66/65 64/63 57/59
Bernard et al 201622 (N=618/580) Asystole/PEA and VF/Pulseless VT Cooled intravenous fluid infusion 24 hours After ROSC 33° Till discharge 23/20 65/64 75/74 66/67

Footnote: CPR=Cardiopulmonary Resuscitation, IH=In-Hospital Hypothermia, N=Number, NT=Normothermia, PEA=Pulseless Electrical Activity, PH=Pre-Hospital Hypothermia, ROSC=Return of Spontaneous Circulation, TTM=Targeted Temperature Management, VF=Ventricular Fibrillation, VT=Ventricular Tachycardia.