Table 2.

The distribution of rare predicted loss of function (pLoF) variants in each pathway in cases and controls.

PAHWAY	% CASES WITH RARE VARIANTS	% CONTROLS WITH RARE VARIANTS	P	OR [95% CI]
RARE VARIANT (ALL)	297/1689 (17.6%)	237/1518 (15.6%)	0.310	1.11 [.91, 1.36]
COMPLEMENT	36/1689 (2.1%)	14/1518 (0.9%)	0.002	2.94 [1.49, 5.79]
ECM	52/1689 (3.1%)	51/1518 (3.4%)	0.610	0.90 [.58, 1.37]
LIPIDS	49/1689 (2.9%)	38/1518 (2.5%)	0.777	1.07 [.67, 1.71]
IMMUNE SYSTEM	14/1689 (0.8%)	6/1518 (0.4%)	0.265	1.78 [.65, 4.89]
METABOLISM	13/1689 (0.8%)	9/1518 (0.6%)	0.838	1.10 [.43, 2.86]
CELL SURVIVAL	28/1689 (1.7%)	18/1518 (1.2%)	0.250	1.46 [.77, 2.76]
UNKNOWN/OTHER	126/1689 (7.5%)	115/1518 (7.6%)	0.555	0.92 [.69, 1.22]

From logistic regression models adjusted for rs1061170 (CFH) and rs10490924 (ARMS2).

ECM = extracellular matrix, OR = odds ratio, CI = confidence interval.