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Vigilance decrement was observed in placebo- but not amphetamine-treated healthy human participants performing the Conners’ CPT-2 as measured by D′ (A), driven in part by changes in target responding (Hit Rate; B) and responses to non-targets (False Alarm Rate; C), across trial blocks. Reaction time and reaction time variability are presented in panels D and E, respectively. Asterisks represent a significant difference from block 1 performance (p < 0.05).
