Figure 4. Relationship between uncertainty adjustment and dopamine.

(A) Changes in uncertainty adjustment following administration of amphetamine. Uncertainty adjustment before and after amphetamine is plotted for subjects above and below the median for the baseline (pre-amphetamine) uncertainty adjustment. (B, C) Scatter plots show that subjects with higher striatal dopamine release capacity have significantly reduced uncertainty adjustment at baseline (pre-amphetamine condition). This is clear in the associative striatum (B, a priori ROI) and the whole striatum (C). The larger plot shows ranked data on both axes and the inset plot shows the raw data for the same variables. The brains depict the manually-traced striatal ROIs of a single subject overlaid on the subject’s T1 anatomical MRI scan. a.u.: arbitrary units. See also Table S1.