Table 1.
Demographic, CNS collection and antipsychotic drug data for cases from which tissue was obtained to study gene expression in Brodmann’s areas 9, 10 and 33
| Age (yr.) | pH | PMI (hr.) | Brain Weight (gms) | Sex | Suicide | DI (yr.) | Cause of death | FRAD | FRADD* | |
|---|---|---|---|---|---|---|---|---|---|---|
| Controls | 59.3 | 6.58 | 20.5 | 1280 | F | Congestive cardiac failure | ||||
| 62.1 | 6.45 | 40 | 1340 | F | Ischaemic heart disease | |||||
| 80.8 | 6.28 | 55 | 1415 | F | Ischaemic heart disease | |||||
| 32.3 | 6.16 | 56 | F | Coronary atheroma | ||||||
| 56.1 | 5.88 | 24 | 1200 | F | Pericardial tamponade | |||||
| 38.8 | 6.26 | 52 | F | Pulmonary thromboembolism | ||||||
| 71.0 | 6.11 | 59 | 1400 | M | Ischaemic heart disease | |||||
| 75.9 | 6.01 | 53 | 1140 | F | Multiple organ failure | |||||
| 75.3 | 6.19 | 69.4 | 1360 | M | Myocardial infarction | |||||
| 55.2 | 6.69 | 30.5 | 1253 | M | Coronary artery atherosclerosis | |||||
| 52.5 | 6.52 | 33.8 | 1400 | M | Cardiomegaly | |||||
| 67.0 | 6.44 | 49.3 | 1190 | F | Aneurysm | |||||
| 66.4 | 6.47 | 71.8 | 1531 | M | Coronary artery atheroma | |||||
| 42.8 | 6.45 | 30.5 | 1500 | M | Ischaemic heart disease | |||||
| Mean | 60 | 6.32 | 46 | 1334 | ||||||
| SD | 14.5 | 0.23 | 16.3 | 124 | ||||||
| Ratio | 6/8 | |||||||||
| Schizophrenia | ||||||||||
| 72.4 | 6.48 | 58.5 | F | N | 37 | Pneumonia | Chlorpromazine | 25 | ||
| 59.1 | 6.44 | 46 | 1300 | F | N | 44 | Congestive cardiac failure | Off drug | ||
| 61.0 | 6.46 | 37.5 | 1365 | M | N | 38 | Ischaemic heart disease | Off drug | ||
| 69.1 | 6.44 | 48 | 1656 | M | Y | 6 | Carbon monoxide poisoning | Off drug | ||
| 38.0 | 6.43 | 20 | 1388 | F | Y | 17 | Burning | Fluphenazine | 485 | |
| 47.3 | 6.31 | 50 | 1570 | F | N | 20 | Pneumonia | Off drug | ||
| 30.0 | 6.37 | 48 | 1455 | F | Y | 10 | Hanging | Chlorpromazine | 600 | |
| 35.3 | 6.38 | 39 | 1480 | F | Y | 9 | Incised wrists | Risperidone | 150 | |
| 59.5 | 6.19 | 44.5 | 1110 | F | N | 35 | Respiratory failure | Clozapine | 632 | |
| 61.2 | 6.01 | 45.5 | 1256 | M | Y | 18 | Hypovolaemic shock | Risperdone | 285 | |
| 65.1 | 6.41 | 56 | 1124 | M | N | 46 | Pneumonia with empyema | Olanzapine | 270 | |
| 58.7 | 6.63 | 42.5 | 1240 | M | N | 36 | Ischaemic heart disease | Zuclopentixol | 506 | |
| 67.0 | 6.19 | 43.5 | 1344 | M | N | 30 | Ischaemic heart disease | Off drug | ||
| 82.3 | 6.13 | 46.5 | 1241 | F | N | 41 | Cardiomegaly | Haloperidol prochlorperazine | 216 | |
| 35.7 | 6.48 | 66 | 1659 | M | Y | 12 | Overdose | Off drug | ||
| Mean | 56 | 6.36 | 46 | 1371 | 27 | 352 | ||||
| SD | 15.4 | 0.16 | 10.4 | 177 | 13.9 | 211 | ||||
| p | 0.53 | 0.63 | 0.99 | 0.55 | ||||||
| Ratios | 7/8 | 6/9 | ||||||||
| p | 0.84 |
DI duration of illness, F female, FRAD final recorded antipsychotic drug dose, FRADD* final recorded antipsychotic
drug dose converted to chlorpromazine equivalents per day, M male, PMI postmortem interval, SD standard deviation