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. 2018 Feb 20;8:3332. doi: 10.1038/s41598-018-21600-w

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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ACEI inhibited fibrosis and scarring in a rat scar model. (A,B) Representative photomicrographs of scar tissue obtained on day 14 with H&E staining (A) or Masson staining (B). Black arrows (A) mark the scales of scars. R: ramipril group; L: losartan group; H: hydralazine group; B: blank control group. (C) Relative scar areas and relative widths in the four groups (n = 12 wounds in six rats in each group). *P < 0.05 compared with the blank control group. H&E staining; images were obtained 40× magnification with an Olympus CKX41SF inverted phase-contrast microscope. Areas were calculated with the Image-Pro Plus v. 6.0 software (Olympus, Japan).