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. 2018 Feb 20;8:3340. doi: 10.1038/s41598-018-21132-3

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Expression pattern of Notch pathway members in kidneys of ARPKD mouse model: (a) Immunohistochemistry (IHC) for N1ICD (Notch1 intracellular domain), N3 (Notch3), Dll4 (Delta like 4), and Hey L was performed on paraffin sections of P7 and P14 WT and cpk kidneys. Arrows point to expression in cyst-lining epithelial cells. Arrowheads in third row point to non-cystic tubular cells with Dll4 expression. Images shown are representative of three independent experiments performed in duplicate. (b) Upper panel represents a no primary antibody control. Lower panel shows IHC for N3 on N3-null mouse kidney section to verify antibody specificity. (c) Western Blot for N3IC and Hey L on lysates of P15 WT and cpk kidneys (n = 3), and of N3-null mouse kidneys to verify antibody specificity. (d) Quantitation of WBs for N3IC and Hey L. **P < 0.01.