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. 2018 Feb 20;8:3372. doi: 10.1038/s41598-018-21638-w

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Comparison between printed channel scaffolds with different cross-sectional areas and perimeter lengths and their CAD design. (a) The median cross-sectional area A of both channel scaffolds show a linear increase with equal slope (untreated: R² = 0.96, heat-treated: R² = 0.91) with growing channel size. However, both overestimate the cross-sectional area of the CAD design for larger channels. (b) Median perimeter length L_p for the samples from (a). Again, untreated (R² = 0.97) and heat-treated (R² = 0.98) channel scaffolds show a linear increase for different sample sizes. Due to their regular surface, the median perimeter length of the heat-treated channels reproduces the CAD design better than the untreated channel scaffolds. The error bars represent the 95% confidence interval determined from 10 slices each for the 20 individual samples.