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. 2018 Feb 20;8:3325. doi: 10.1038/s41598-018-21718-x

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Genetic commonalities between neural tube defects and bone-associated genes are enriched for pathways with critical skeletal functions. (A) Schematic of the processes by which the extent of known genetic commonality was determined. (B) “Bone”, “osteoblast” and “osteoclast” associated gene ontology terms enriched in the NTD genes list. (C) LinkDB map of interacting genes in the Overlap list. (D) Signalling pathways enriched in the Overlap list.