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. 2018 Feb 16;9:209. doi: 10.3389/fmicb.2018.00209

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Copyright © 2018 Dong, Dong, Yu, Huang, Jiang, Hu, Chen, Lu and Pan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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LD50 analysis of transgenic silkworm lines. LD50 analysis of transgenic hybrid lines Cas9(–)/sgRNA(–) and Cas9(+)/sgRNA(+) after inoculation of fourth instar larvae with BmNPV with 1 × 10³, 1 × 10⁴, 1 × 10⁵, 1 × 10⁶, 1 × 10⁷, and 1 × 10⁸ OBs/larva, respectively. Each transgenic line was screened in triplicate, with each replicate consisting of 30 larvae. The mortality rate was calculated starting from 4 to 8 days after infection using different OB concentrations.