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. 2018 Feb 16;8:26. doi: 10.3389/fonc.2018.00026

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Copyright © 2018 Bailey, Collins, Tunariu, Orton, Morgan, Feiweier, Hawkes, Leach, Alexander and Panagiotaki.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Correlation plots combining voxel data for all patients, with regions of interest (ROIs) separated by color. Linear regression on combined data from the seven non-fatty ROIs demonstrated significant correlation between apparent diffusion coefficient (ADC) and vascular, extracellular, and restricted diffusion for cytometry in tumors (VERDICT) [Ball–Ball–Sphere (BBS)] parameters D_I, f_I, and f_p. These same three VERDICT parameters correlate with D_kurt, whereas K correlates with f_I and, more weakly, with R and D_I.