Table 1.

Novel anti-oxidative agents that ameliorate renal fibrosis.

Agent	Target	Finding
Cysteamine bitartrate	Cellular ROS production; may increase intracellular glutathione pools	Decreased renal fibrosis in UUO and IR models
PXS-4728A	Inhibits Semicarbazide-sensitive amine oxidases (SSAOs)	Reduced renal fibrosis in UUO and cisplatin-induced AKI
AUDA/t-TUCB	Inhibitors of soluble epoxide hydrolase (sEH)	Reduced proteinuria-induced epithelial-mesenchymal transition and myofibroblast levels; prevented renal interstitial fibrogenesis in UUO model
Cytoglobin	Scavenges reactive oxygen species (ROS)	Preserved renal function and reduced fibrosis in remnant kidney model

AKI, acute kidney injury; IR, ischemia-reperfusion; ROS, reactive oxygen species; UUO, unilateral ureteral obstruction.