Table 1.
Lowest effective (p ≤ 0.05) tested doses of chemicals in human hematopoietic stem cells (HSC) and human lymphoblastoid TK6 cells.
| HSC | TK6 | Factor dose HSC/dose TK6 | |
|---|---|---|---|
| Doxorubicin (nM) | |||
| Mn-cells/1,000 bn-cells | 200 | 5 | 40 |
| Proliferation (CBPI) | 500 | 50 | 10 |
| Apoptosis (o/oo) | (500) | 200 | — |
| Viability (% viable) | (500) | 50 | — |
| Vinblastine (nM) | |||
| Mn-cells/1,000 bn-cells | 100 | 10 | 10 |
| Proliferation (CBPI) | 150 | 20 | 7.5 |
| Apoptosis (o/oo) | 200 | 10 | 20 |
| Viability (% viable) | (200) | 10 | — |
| MMS (µM) | |||
| Mn-cells/1,000 bn-cells | 250 | 100 | 2.5 |
| Proliferation (CBPI) | 375 | 250 | 1.5 |
| Apoptosis (o/oo) | 375 | 100 | 3.75 |
| Viability (% viable) | 375 | 250 | 1.5 |
| MMC (µM) | |||
| Mn-cells/1,000 bn-cells | 0.1 | 0.1 | 1 |
| Proliferation (CBPI) | 0.5 | 0.5 | 1 |
| Apoptosis (o/oo) | 1 | 1 | 1 |
| Viability (% viable) | 1 | 10 | 0.1 |
If no significant effect was induced at the tested doses, the maximal tested dose is given, but no dose factor is calculated. Mn-cells/1,000 bn-cells = micronucleated cells/1,000 binucleated cells. MMS = methyl methanesulfonate; MMC = mitomycin C.