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Pedigree of a family with individuals affected by POAG. The (c.109G>A; p.Val37Met) variant in the TP53BP2 gene is indicated with M2, the variant (c.305G >A; p.Arg102His) in the MAPKAPK2 gene is indicated with M1, and the wild type allele is indicated with WT for both genes together with microsatellite markers haplotype. All affected individuals carry both variants heterozygously, while the unaffected individuals do not carry the variant
