Table 1.

Clinical features of patients with primary open angle glaucoma with the TP53BP2 mutation

Patient number	Gender	Age at participation	Age at diagnosis	Presenting IOP	Laterality	Iris diaphany	Filtering surgery	Visual field loss at HFAa	MRA grade at HRTb	Presenting MD (dB) on Humphrey perimetry*	Presenting CPSD (dB) on Humphrey perimetry*
III:1	Female	78	49	13	Bilateral	No	Yes	In both eyes	Outside normal limits ODS	−30.49	4.05
III:2	Female	66	53	15	Bilateral	Yes	Yes	In both eyes	Borderline OD/outside normal limits OS	−24.58	11.00
III:3	Female	74	?	16	Bilateral suspect	No	No	OD	Outside normal limits OD/borderline OS	−3.90	3.05
III:4	Male	71	54	11	Bilateral	No	Yes	In both eyes	Outside normal limits ODS	−30.69	4.00
III:5	Female	70	54	9	Bilateral	Yes	Yes	In both eyes	Outside normal limits ODS	−31.10	3.11
III:6	Female	68	50	14	Bilateral	No	No	In both eyes	Borderline OD/outside normal limits OS	−15.82	12.87
III:7	Male	76	61	15	Bilateral	No	Yes	In both eyes	Outside normal limits ODS	−17.44	11.52
III:9	Female	79	63	13	Bilateral	No	No	In both eyes	Outside normal limits ODS	−9.99	8.02
Mean ± SD		72.7 ± 4.4	54.8 ± 4.8	13.2 ± 2.2

IOP as measured by applanation tonometry in both eyes, presence of typical glaucomatous optic neuropathy with compatible visual field loss, open drainage angels on gonioscopy, and the absence of a secondary cause for glaucomatous optic neuropathy

IOP intraocular pressure, Presenting IOP highest IOP of two measurements in both eyes, HFA Humphrey Field Analyzer, MRA Moorfields regression analysis, HRT Heidelberg Retina Tomograph II, SD standard deviation, OD right eye, OS left eye, ODS both eyes

*Of worst affected visual field

^aVisual filed loss on HFA, as defined by the HODAPP classification [24]

^bMRA has three grades: “within normal limits,” “borderline,” and “outside normal limits”