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. 2017 Nov 22;55(2):1795–1813. doi: 10.1007/s12035-017-0824-8

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© The Author(s) 2017

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 3 — Brain-derived ELOVL4 products are 28:0 and 30:0 that are enriched in synaptic vesicle membranes. Electron micrographs of synaptic fractions isolated from baboon hippocampus by sucrose gradient centrifugation (scale bar = 500 nm). a Starting homogenate (Homo.) with a single neurosynaptosomal unit (arrow). b Neurosynaptosomal fraction (Synapt.) with multiple neurosynaptosomes in frame (arrows). c Post-synaptic density fraction (PSD) with multiple isolated densities indicated (arrows). d Synaptic vesicle fraction (SV) with high purity, vesicle indicated in zoomed inset (arrow). e Lipidomic analysis (GC-MS followed by GC-FID) reveals enrichment of both 28:0 and 30:0 in synaptic vesicle membranes relative to the other synaptic fractions. Statistics: two-way ANOVA with Tukey’s multiple comparison test, ****p < 0.0001 (n = 3) error ± SEM