Table 3.
mAb neutralization of A/Shanghai/2/2013 escape mutants
| Virusa | mAbb | |||
|---|---|---|---|---|
| 5A6 | 7B5 | 1E9 | 98 | |
| A/Shanghai/2/2013 | +++ | +++ | +++ | +++ |
| 5A6v (R131G) | ‐ | ++ | ++ | +++ |
| 7B5v (G189E) | ++ | ‐ | ++ | +++ |
| 1E9v (R247H) | + | +++ | ‐ | +++ |
| 98v (G119E/K157E) | + | ++ | ‐ | ‐ |
a
Each virus was titrated and diluted to approximately 500 pfu/mL and incubated with mAb concentrations from 80 to 0.31 μg/mL for incubation with mAb.
b
(‐) No virus neutralization at mAb >80 μg/mL; (+) neutralization at 20 μg/mL; (++) neutralization at 5 μg/mL; (+++) neutralization at mAb between 0.31 and 1.25 μg/mL.