Table 2.
Top 10 differentially expressed genes identified in meta-analysis.
| *Entrez ID | Gene symbol | Gene name | Fold change (FC) | #Adjusted p-value | ||
|---|---|---|---|---|---|---|
| (A) Endometriosis (EMS) | ||||||
| TOP 10 UP-REGULATED GENES | ||||||
| 170302 | ARX | Aristaless related homeobox | 6.16 | 7.60E-16 | ||
| 5010 | CLDN11 | Claudin 11 | 6.08 | 2.53E-13 | ||
| 55026 | TMEM255A | Transmembrane protein 255A | 4.66 | 8.09E-10 | ||
| 1295 | COL8A1 | Collagen type VIII alpha 1 chain | 4.49 | 2.25E-08 | ||
| 6332 | SCN7A | Sodium voltage-gated channel alpha subunit 7 | 3.92 | 2.23E-06 | ||
| 4915 | NTRK2 | Neurotrophic receptor tyrosine kinase 2 | 3.54 | 5.72E-07 | ||
| 345557 | PLCXD3 | Phosphatidylinositol specific phospholipase C X domain containing 3 | 3.41 | 7.69E-09 | ||
| 23224 | SYNE2 | Spectrin repeat containing nuclear envelope protein 2 | 3.39 | 1.63E-10 | ||
| 55220 | KLHDC8A | Kelch domain containing 8A | 3.35 | 1.09E-02 | ||
| 5549 | PRELP | Proline and arginine rich end leucine rich repeat protein | 3.35 | 1.43E-04 | ||
| TOP 10 DOWN-REGULATED GENES | ||||||
| 115111 | SLC26A7 | Solute carrier family 26 member | −4.29 | 2.28E-08 | ||
| 56547 | MMP26 | Matrix metallopeptidase 26 | −4.25 | 3.34E-04 | ||
| 9848 | MFAP3L | Microfibril associated protein 3 | −3.75 | 1.81E-03 | ||
| 100133941 | CD24 | CD24 molecule | −3.42 | 2.01E-06 | ||
| 57535 | KIAA1324 | KIAA1324 | −3.42 | 3.38E-05 | ||
| 3170 | FOXA2 | Forkhead box A2 | −3.29 | 1.37E-07 | ||
| 1750 | DLX6 | Distal-less homeobox 6 | −3.20 | 7.93E-05 | ||
| 3213 | HOXB3 | Homeobox B3 | −3.19 | 1.16E-08 | ||
| 64321 | SOX17 | SRY-box 17 | −3.15 | 1.19E-05 | ||
| 27324 | TOX3 | TOX high mobility group box family member 3 | −3.10 | 2.20E-02 | ||
| (B) Multiple sclerosis (MS) | ||||||
| TOP 10 UP-REGULATED GENES | ||||||
| 3706 | ITPKA | Inositol-trisphosphate 3-kinase A | 6.63 | 2.24E-02 | ||
| 57495 | NWD2 | NACHT and WD repeat domain containing 2 | 6.28 | 2.24E-02 | ||
| 9312 | KCNB2 | Potassium channel, voltage gated Shab related subfamily B, member 2 | 6.05 | 2.55E-02 | ||
| 9495 | AKAP5 | A kinase (PRKA) anchor protein 5 | 5.94 | 3.16E-02 | ||
| 59350 | RXFP1 | Relaxin/insulin-like family peptide receptor 1 | 5.86 | 1.63E-02 | ||
| 2845 | GPR22 | G protein-coupled receptor 22 | 5.75 | 5.03E-02 | ||
| 29953 | TRHDE | Thyrotropin-releasing hormone degrading enzyme | 5.34 | 2.35E-02 | ||
| 118427 | OLFM3 | Olfactomedin 3 | 5.10 | 3.26E-02 | ||
| 440279 | UNC13C | unc-13 homolog C (C. elegans) | 5.08 | 2.82E-02 | ||
| 2561 | GABRB2 | Gamma-aminobutyric acid (GABA) A receptor, beta 2 | 5.05 | 2.46E-02 | ||
| TOP 10 DOWN-REGULATED GENES | ||||||
| 116835 | HSPA12B | Heat shock 70kD protein 12B | −15.90 | 5.19E-02 | ||
| 7276 | TTR | Transthyretin | −8.19 | 3.97E-02 | ||
| 1586 | CYP17A1 | Cytochrome P450, family 17, subfamily A, polypeptide 1 | −6.75 | 2.12E-02 | ||
| 3284 | HSD3B2 | Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 | −6.58 | 1.36E-02 | ||
| 8788 | DLK1 | Delta-like 1 homolog (Drosophila) | −6.13 | 2.12E-02 | ||
| 53637 | S1PR5 | Sphingosine-1-phosphate receptor 5 | −5.92 | 7.78E-03 | ||
| 8513 | LIPF | Lipase F, gastric type | −5.57 | 2.24E-02 | ||
| 3126 | HLA-DRB4 | Major histocompatibility complex, class II, DR beta 4 | −5.55 | 3.08E-02 | ||
| 5015 | OTX2 | Orthodenticle homeobox 2 | −5.30 | 2.06E-02 | ||
| 1584 | CYP11B1 | Cytochrome P450, family 11, subfamily B, polypeptide 1 | −5.18 | 2.61E-02 | ||
| (C) Shared DEGs between EMS and MS | ||||||
| *Entrez ID | Gene symbol | Gene name | Fold change (FC) | #Adjusted p-value | ||
| EMS | MS | EMS | MS | |||
| TOP 10 UP-REGULATED GENES | ||||||
| 343450 | KCNT2 | Potassium channel, sodium activated subfamily T, member 2 | 2.71 | 4.08 | 4.15E-08 | 3.32E-02 |
| 1301 | COL11A1 | Collagen, type XI, alpha 1 | 2.60 | 4.18 | 3.49E-05 | 2.12E-02 |
| 257194 | NEGR1 | Neuronal growth regulator 1 | 2.19 | 4.32 | 1.81E-06 | 4.02E-02 |
| 27303 | RBMS3 | RNA binding motif, single stranded interacting protein 3 | 1.72 | 4.67 | 3.20E-03 | 2.06E-02 |
| 4057 | LTF | Lactotransferrin | 2.39 | 3.94 | 3.18E-04 | 1.74E-07 |
| 345557 | PLCXD3 | Phosphatidylinositol-specific phospholipase C, X domain containing 3 | 3.41 | 2.85 | 7.69E-09 | 3.51E-02 |
| 627 | BDNF | Brain-derived neurotrophic factor | 2.67 | 3.50 | 7.37E-08 | 4.29E-02 |
| 1131 | CHRM3 | Cholinergic receptor, muscarinic 3 | 1.65 | 4.37 | 3.33E-03 | 2.95E-02 |
| 283078 | MKX | Mohawk homeobox | 3.16 | 2.82 | 2.95E-07 | 2.12E-02 |
| 2823 | GPM6A | Glycoprotein M6A | 2.10 | 3.73 | 2.11E-04 | 2.76E-02 |
| TOP 10 DOWN-REGULATED GENES | ||||||
| 7368 | UGT8 | UDP glycosyltransferase 8 | −2.81 | −4.30 | 2.11E-06 | 5.02E-02 |
| 6319 | SCD | WSC domain containing 2 | −1.51 | −4.68 | 6.18E-04 | 3.59E-02 |
| 2065 | ERBB3 | Erb-b2 receptor tyrosine kinase 3 | −2.56 | −3.41 | 3.99E-05 | 2.11E-02 |
| 135932 | TMEM139 | Transmembrane protein 139 | −1.72 | −3.71 | 4.39E-03 | 4.57E-02 |
| 57475 | PLEKHH1 | Pleckstrin homology domain containing, family H (with MyTH4 domain) member 1 | −1.85 | −3.57 | 6.15E-03 | 2.79E-02 |
| 6299 | SALL1 | Spalt-like transcription factor 1 | −2.35 | −2.61 | 3.81E-10 | 4.12E-02 |
| 3092 | HIP1 | Huntingtin interacting protein 1 | −2.14 | −2.73 | 6.53E-04 | 2.92E-02 |
| 4678 | NASP | Nuclear autoantigenic sperm protein (histone-binding) | −2.35 | −2.08 | 1.18E-03 | 3.68E-02 |
| 9043 | SPAG9 | Sperm associated antigen 9 | −1.53 | −2.85 | 2.98E-03 | 3.08E-02 |
| 3696 | ITGB8 | Integrin, beta 8 | −1.61 | −2.73 | 1.73E-03 | 5.25E-02 |
*
Bold and underlined gene IDs denoted to the existence of these genes in OMIM and DisGeNET disease databases.
#
p-values are adjusted, based on the False Discovery Rate (FDR) using the Benjamini–Hochberg method.