Table 3.
Crosstalk interactions through overlapping edges in pathways that is significantly dysregulated (P < 0.05) in both EMS and MS.
| KEGG ID | Pathway | Classification | Hits | Node | Edge | DEGs in PPI network | Figure |
|---|---|---|---|---|---|---|---|
| hsa04310 | Wnt signaling pathway | Signal transduction | 8 | 8 | 13 | &TBL1XR1; &TBL1X; &APC; &TCF7L2; &PSEN1; &MAPK10 ; $SOX17; $CTNNB1 | Figure 6A |
| hsa04670 | Leukocyte transendothelial migration (a) | Immune system | 5 | 5 | 2 | &ACTB; &CTNND1; &CTNNA3; &MYL12B ; $CTNNB1 | Figure 6B |
| hsa04110 | Cell cycle | Cell growth and death | 5 | 5 | 6 | &ATM; &ANAPC5 ; $RAD21; $ANAPC4; #CCNB1 | Figure 6C |
| hsa04114 | Oocyte meiosis | Cell growth and death | 4 | 4 | 4 | &RPS6KA3; &ANAPC5; $ANAPC4; #CCNB1 | Figure 6D |
| hsa04666 | Fc gamma R-mediated phagocytosis | Immune system | 3 | 3 | 3 | &CRKL; &PIK3R1 ; $GAB2 | Figure 6E |
| hsa04670 | Leukocyte transendothelial migration (b) | Immune system | 3 | 3 | 3 | &PTK2; &PIK3R1; $ITGB1 | Figure 6F |
Genes from EMS;
genes from MS;
shared genes between EMS and MS.
ACTB, actin, beta; ANAPC4, anaphase promoting complex subunit 4; ANAPC5, anaphase promoting complex subunit 5; APC, adenomatous polyposis coli; ATM, ataxia telangiectasia mutated; CCNB1, cyclin B1; CRKL, v-crk sarcoma virus CT10 oncogene homolog (avian)-like; CTNNA3, catenin (cadherin-associated protein), alpha 3; CTNNB1, catenin (cadherin-associated protein), beta 1, 88kDa; CTNND1, catenin (cadherin-associated protein), delta 1; GAB2, GRB2-associated binding protein 2; ITGB1, integrin, beta 1; MAPK10, mitogen-activated protein kinase 10; MYL12B, myosin, light chain 12B; PIK3R1, phosphoinositide-3-kinase, regulatory subunit 1 (alpha); PSEN1, presenilin 1; PTK2, PTK2 protein tyrosine kinase 2; RAD21, RAD21 homolog (S. pombe); RPS6KA3, ribosomal protein S6 kinase, 90kDa, polypeptide 3; SOX17, SRY (sex determining region Y)-box 17; TBL1X, transducin (beta)-like 1X-linked; TBL1XR1, transducin (beta)-like 1 X-linked receptor 1; TCF7L2, transcription factor 7-like 2 (T-cell specific, HMG-box).