Table 7.

Crosstalk interactions through shared overlapping genes or immunomodulatory proteins as probable linker in EMS and MS.

Shared genes	Description	#EMS	#MS	Dysregulated shared pathways	Classification
UP-REGULATION IN BOTH EMS AND MS
NEGR1	Neuronal growth regulator 1	↑	↑	Cell adhesion molecules (CAMs)	Signaling molecules and interaction
LEPR	Leptin receptor	↑	↑	Cytokine-cytokine receptor interaction	Signaling molecules and interaction
CHRM3	Cholinergic receptor muscarinic 3	↑	↑	Neuroactive ligand-receptor interaction/// Calcium signaling pathway	Signaling molecules and interaction/// Signal transduction
ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	↑	↑	Oocyte meiosis///Calcium signaling pathway	Cell growth and death/// Signal transduction
DOWN-REGULATION IN BOTH EMS AND MS
SLC8A1	Solute carrier family 8 member A1	↓	↓	Calcium signaling pathway	Signal transduction
ERBB3	Erb-b2 receptor tyrosine kinase 3	↓	↓	Calcium signaling pathway///ErbB signaling pathway	Signal transduction
CDH1	Cadherin 1	↓	↓	Cell adhesion molecules (CAMs)	Signaling molecules and interaction
ITGB8	Integrin subunit beta 8	↓	↓	Cell adhesion molecules (CAMs)///ECM-receptor interaction	Signaling molecules and interaction
PTPN11	Protein tyrosine phosphatase, non-receptor type 11	↓	↓	Leukocyte transendothelial migration	Immune system
PPP2R5E	Protein phosphatase 2 regulatory subunit B'epsilon	↓	↓	Oocyte meiosis	Cell growth and death

# Up arrow, denotes to upregulation of genes.

# Down arrow, denotes to downregulation of genes.