Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Feb 16;9:46. doi: 10.3389/fphar.2018.00046

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2018 Malkawi, Alzoubi, Jacob, Matic, Ali, Al Faraj, Almuhanna, Dasouki and Abdel Rahman.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Analysis of metabolic pathways. (A) Summary of pathway analysis for the most relevant pathways involved under experiment conditions. (B) Tryptophan-kynurenine metabolism pathway. Dexamthesaone inhibits kenureninase which causes accumulation of kynurenine, 3-hydroxy-kenurenine, tryptophan and secondarily serotonin (5-hydroxytryptamine). Dex treatment causes significant elevation in serum levels of tyrosine (C) and hydroxyproline (D) and significant reduction in phenylalanine, lysine and arginine.