AC1 |
Lipid raft |
β2AR |
Vascular smooth muscle cells |
AC1 overexpression used to demonstrate GPCR coupling |
AC2 |
Nonraft |
EP2/4R |
Airway smooth muscle cells |
AC2 overexpression used to demonstrate GPCR coupling |
AC3 |
Lipid raft |
β2AR, D1R glucagon |
HEK-293 |
Glucagon receptors were exogenously expressed |
AC4 |
Nonraft |
Unknown |
Unknown |
|
AC5 |
Lipid raft |
β1AR, β2AR, A2AR |
Cardiac myocytes, hepatocytes |
D5R couple to AC5 in nonrafts of renal tubule cells |
AC6 |
Lipid raft |
β1AR, β2AR, IPR, D1, A2AR, PAC1
|
HEK-293, cardiac myocytes, airway and GI smooth muscle cells, vascular smooth muscle cells, cardiac fibroblasts, lung fibroblasts, hepatocytes, platelets |
AC6 overexpression, knockdown, and antibody inactivation have been used to determine GPCR-AC6 coupling |
AC7 |
Nonraft |
D1R-EP1R |
HEK-293 |
Regulation of AC7 by D1R is via Gβγ and requires EP1R |
AC8 |
Lipid raft |
None |
HEK-293, pancreatic cells, hippocampal neurons |
Stimulated by store-operated and L-type calcium channels |
AC9 |
Nonraft |
Unknown |
Unknown |
|