Table 4.
Crystallized lactose based DPI formulations.
| Drug | Method | Key ingredients | Device and flow rate | % FPF | References |
|---|---|---|---|---|---|
| (l/min) | |||||
| SS | ASC | Lactochem and acetone : water (85 : 15) |
Rotahaler and 60 | 26.9 ± 1.8 | [23] |
| SS | ASC | Ethanol : butanol (20 : 60) | - | 38.0 ± 2.5 | [24] |
| SS | ASC | Ethanol : acetone (40 : 40) | Aerolizer and 92 | 40.48 ± 4.57 | [25] |
| SS | ASC | Pharmatose 100 M and ethanol : butanol |
Aerolizer and 92 | - | [8] |
| SS | ASC | Pharmatose 100 M and butanol : acetone (80 : 00) |
Aerolizer and 92 | - | [26] |
ASC: antisolvent crystallization; SS: salbutamol sulphate.