Table 5.
Spray-dried lactose loaded DPI formulations.
| Drug | Method | Key | PSD | Device and flow | % FPF | References |
|---|---|---|---|---|---|---|
| ingredients | (μm) | rate (l/min) | ||||
| Pranlukast hydrate | SD | Pharmatose 200 M and Pharmatose 325 M | <90 | Spinhaler® and 60 | 28.5 ± 3.1 | [35] |
| Human serum albumin | SD | Albumin : lactose : DPPC (30 : 10 : 60) | 6.50 | Spinhaler and 28.3 | 41 ± 5.0 | [36] |
| SS | SD | Lactochem crystals | 77.72 | Cyclohaler and 60 | 31.3 ± 1.3 | [37] |
| Budesonide | SD | α-LM | >230 | ∗Taifun® | 31.0 ± 5.1 | [38] |
∗Taifun is a multiple dose, reservoir-based DPI. DPPC: dipalmitoyl phosphatidylcholine; FPF: fine particle fraction.