Table 2.
Significant changes of NER expression between different types of CRC and normal tissues.
| Gene | Compared group | Up/down | Fold change | t-test | P value | Dataset |
|---|---|---|---|---|---|---|
| ERCC1 | Colon adenocarcinoma versus normal | ↑ | 3.075 | 11.744 | 1.67E − 13 | TCGA colorectal |
| Rectal adenocarcinoma versus normal | ↑ | 3.813 | 12.954 | 1.79E − 16 | TCGA | |
| Colon carcinoma versus normal | ↑ | 2.391 | 8.249 | 1.68E − 06 | Skrzypczak Colorectal 2 | |
|
| ||||||
| ERCC2 | Colon adenoma versus normal | ↑ | 2.813 | 8.805 | 3.18E − 12 | Sabates-Bellver Colon |
| Rectal adenoma versus normal | ↑ | 3.008 | 7.979 | 7.63E − 08 | Sabates-Bellver Colon | |
|
| ||||||
| ERCC4 | Rectosigmoid adenocarcinoma versus normal | ↓ | −2.271 | −5.151 | 0.009 | TCGA colorectal |
|
| ||||||
| ERCC5 | Rectal mucinous adenocarcinoma versus normal | ↑ | 2.121 | 4.362 | 0.005 | Kaiser Colon |
|
| ||||||
| DDB2 | Colon adenoma versus normal | ↑ | 3.159 | 10.848 | 4.80E − 14 | Sabates-Bellver Colon |
| Rectal adenoma versus normal | ↑ | 2.890 | 5.475 | 4.30E − 04 | Sabates-Bellver Colon | |