Figure 1. Study Flowchart of High-Cutoff vs Conventional Hemodialysis.

^aEntered another randomized study comparing 2 bortezomib-based chemotherapeutic regimens (bortezomib and dexamethasone vs bortezomib, cyclophosphamide, and dexamethasone) for kidney outcome.

^bRequired treatment with hemodialysis because of the presence of at least 1 of the following: hyperkalemia, metabolic acidosis, fluid overload, or symptoms of uremia.

^cAllows efficient serum immunoglobulin light chain removal through very large membrane pores.

^dIn accordance with the intention-to-treat principle, this patient was included in the analysis of the high-cutoff hemodialysis group.