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Histopathological study (A) control group. (B) MP14 group ((A), (B)×200). Osteonecrosis was not found in any of the animals in either C group. In MP14 group, osteonecrosis was found in 7 of animals (70%).Osteocytes in the stained bone contain achromatic nuclei or empty lacunase, showing typical features of osteonecrosis. Medulally hematopoietic cells around the site of osteonecrosis are interspersed with necrotic and degenerated cells.
