Table 3.

Univariate Cox regression analyses estimating the influence of cMK2 and nETV1 and clinicopathologic parameters on overall survival (OS) and disease free survival (DFS).

		p-value univariate	RR	95% CI				p-value univariate	RR	95% CI
Overall Survival						Disease Free Survival
All						All
cMK2		0.01	1.352	1.08 - 1.70		cMK2		0.076	1.23	0.98 - 1.55
nETV1		0.006	0.491	0.30 - 0.82		nETV1		0.091	0.662	0.41 - 1.07
(y)pT		< 0.001	1.484	1.23 - 1.70		(y)pT		< 0.001	1.411	1.23 - 1.62
(y)pN		< 0.001	1.336	1.21 - 1.48		(y)pN		< 0.001	1.361	1.23 - 1.51
UICC Staging		< 0.001	1.903	1.45 - 2.49		UICC Staging		< 0.001	1.739	1.33 - 2.28
(y)pG		< 0.001	1.402	1.17 - 1.69		(y)pG		0.002	1.336	1.11 - 1.61
R		0.92	1.017	0.73 - 1.42		R		0.579	1.1	0.79 - 1.54
Age		< 0.001	0.976	0.97 - 0.99		Age		< 0.001	0.975	0.97 - 0.99
Sex		0.0518	0.765	0.58 - 1.00		Sex		0.208	0.841	0.64 - 1.10
NT		< 0.001	1.714	1.30 - 2.25		NT		< 0.001	1.77	1.35 - 2.33
AT		< 0.001	0.623	0.50 - 0.78		AT		< 0.001	0.66	0.53 - 0.83
AC						AC
cMK2		0.016	1.445	1.07 - 1.95		cMK2		0.125	1.261	0.94 - 1.70
nETV1		0.018	0.423	0.21 - 0.86		nETV1		0.102	0.571	0.29 - 1.12
(y)pT		< 0.001	1.579	1.31 - 1.91		(y)pT		< 0.001	1.575	1.30 - 1.91
(y)pN		< 0.001	1.389	1.22 - 1.58		(y)pN		< 0.001	1.384	1.21 - 1.60
UICC Staging		< 0.001	1.927	1.36 - 2.73		UICC Staging		< 0.001	1.828	1.29 - 2.60
(y)pG		< 0.001	1.566	1.20 - 2.04		(y)pG		0.002	1.508	1.16 - 1.96
R		0.699	1.092	0.70 - 1.71		R		0.435	1.196	0.76 - 1.88
Age		0.001	0.979	0.97 - 0.99		Age		< 0.001	0.976	0.96 - 0.99
Sex		0.532	0.887	0.61 - 1.29		Sex		0.713	0.932	0.64 - 1.36
NT		< 0.001	1.812	1.27 - 2.58		NT		< 0.001	2.087	1.46 - 2.98
AT		0.008	0.676	0.51 - 0.90		AT		0.032	0.728	0.54 - 0.97
SCC						SCC
cMK2		0.064	1.447	0.98 - 2.14		cMK2		0.06	1.44	0.98 - 2.12
nETV1		0.199	0.621	0.30 - 1.29		nETV1		0.437	0.76	0.38 - 1.52
(y)pT		0.002	1.3	1.12 - 1.66		(y)pT		0.029	1.241	1.02 - 1.51
(y)pN		< 0.001	1.366	1.14 - 1.64		(y)pN		< 0.001	1.518	1.25 - 1.85
UICC Staging		0.005	1.831	1.20 - 2.80		UICC Staging		0.0256	1.62	1.06 - 2.48
(y)pG		0.01	1.474	1.09 - 1.99		(y)pG		0.03	1.386	1.03 - 1.86
R		0.652	0.888	0.53 - 1.49		R		0.883	0.96	0.57 - 1.63
Age		0.002	0.973	0.96 - 0.99		Age		0.006	0.976	0.96 - 0.99
Sex		0.022	0.631	0.43 - 0.93		Sex		0.052	0.674	0.45 - 1.00
NT		0.036	1.6	1.03 - 2.48		NT		0.079	1.488	0.96 - 2.32
AT		< 0.001	0.495	0.34 - 0.71		AT		< 0.001	0.474	0.33 - 0.69

RR = relative risk; CI = confidence interval; cMK2 = cytoplasmic (MAPK)-activated protein kinase 2; nETV1 nuclear of Ets variant gene 1; AC = adenocarcinomas; SCC = squamous cell carcinomas; R = resection margin; UICC = Union for International Cancer Control; NT = neoadjuvant therapy; AT = adjuvant therapy