Table 1.
The overall common characteristics of our enrolled 81 HNETs patients
| Characteristics | Primary HNETs | HNETs with unknown origin | P value |
|---|---|---|---|
| Age at onset, mean (SD) (median), y | 60.69 (13.60) (60) | 58.91 (9.98) (59) | 0.501 |
| Male, n (%) | 26 (74.29%) | 27 (58.7%) | 0.110 |
| Female, n (%) | 9 (25.71%) | 19 (41.3%) | |
| Hepatic tumor location (for single lesion), n (%) | 18 (51.43%) | 23 (50%) | 0.539 |
| III segment | 5 (14.29%) | 8 (17.39%) | |
| IV segment | 2 (5.71%) | 10 (21.74%) | |
| II segment | 4 (11.43%) | 3 (6.52%) | |
| Other segments | 7 (20%) | 2 (4.35%) | |
| Multifocal tumors, n (%) | 17 (48.57%) | 23 (50%) | 0.539 |
| Tumor diameter, mean (median) (SD), cm | 6.73 (6) (4.62) | 6.93 (6.5) (4.08) | 0.840 |
| Hepatic tumor load, mean (median) , cm3 | 211.1 (30) | 76.66 (35) | 0.036 |
| Detection of regional lymph node metastases, n (%) | 10 (28.57%) | 4 (8.70%) | 0.020 |
| Portal vein tumor thrombus, n (%) | 0.001 | ||
| Positive | 32 (91.43%) | 35 (76.09%) | |
| Negative | 3 (8.57%) | 11 (23.91%) | |
| Extra organ invasion at diagnosis, n (%) | 6 (17.14%) | 4 (8.70%) | 0.210 |
| Gall bladder | 1 | 2 | |
| Posterior peritoneum | 2 | 0 | |
| Lung | 2 | 1 | |
| Spleen | 1 | 0 | |
| Pancreas | 0 | 1 | |
| Necrosis, n (%) | 11 (31.43%) | 5 (10.87%) | 0.022 |
| Tumor texture, n (%) | 0.602 | ||
| Soft | 1 (2.94%) | 2 (4.35%) | |
| Hard | 34 (97.06%) | 44 (95.65%) | |
| WHO grade, n (%) | 0.564 | ||
| G1 | 2 (5.71%) | 2 (4.34%) | |
| G2 | 7 (20%) | 14 (30.43%) | |
| G3 | 26 (74.29%) | 30 (65.23%) | |
| Tumor differentiation, n (%) | 0.070 | ||
| Well-differentiated | 5 (14.29%) | 4 (8.70%) | |
| Moderately-differentiated | 21 (60%) | 21 (45.65%) | |
| Poorly-differentiated | 9 (25.71%) | 21 (45.65%) | |
| Ki-67 index, mean (SD) (median) | 26.80 (20.62) (21) | 22.20 (16.25) (20.50) | 0.264 |
| Mitotic count, mean (SD) (median) | 6.54 (5.10) (5) | 8.54 (6.49) (8) | 0.137 |