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Schemastic illustration of MICAL2 functions. MICAL2 induces F-actin depolymerization by redox modification. The depolymerization of F-actin reduces G-actin and accumulates MRTF-A through clustering. The accumulation of MRTF-A in nucleus actives SRF/MRTF-A-dependent gene transcription, and finally promotes cancer cells migration and invasion.
