Table 1.
The functions of MICALs
| MICAL | associated protein | Function | Reference |
|---|---|---|---|
| Mical-1 | vimentin and CasL | cytoskeletal rearrangement | 1 |
| CRMP-2 | Axon guidance | 28 | |
| PlexA-1 | Axon guidance | 17 | |
| NDR1 | apoptosis | 20 | |
| Mical-2 | F-actin | cytoskeletal rearrangement | 14 |
| Rab1 | vesicle trafficking | 29 | |
| Mical-3 | Rab8A and ELKS | vesicle docking and fusion | 25 |
| F-actin | cytoskeletal rearrangement | 14 | |
| Mical-L1 | Rab8,10, 13,15,35 and36 | recycling endosomes and regulating trafficking | 30 |
| EHD1 | Focal adhesion and endocytic function | 31, 32 | |
| Mical-L2 | Rab13 | neurite outgrowth and exocytosis | 33, 34 |
| F-actin | cytoskeletal rearrangement | 35 |