Table 1.
Association between NEFL gene polymorphisms and neuroblastoma susceptibility
| Genotype | Guangdong province | Henan province | Combined subjects | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cases (N=255) |
Controls (N=531) |
Adjusted OR (95% CI) a |
P a | Cases (N=118) |
Controls (N=281) |
Adjusted OR (95% CI) a |
P a | Cases (N=373) |
Controls (N=812) |
Adjusted OR (95% CI) a |
P a | |
| rs11994014 G>A (HWE=0.513 for combined subjects) | ||||||||||||
| GG | 83 (32.55) | 186 (35.03) | 1.00 | 47 (39.83) | 115 (40.93) | 1.00 | 130 (34.85) | 301 (37.07) | 1.00 | |||
| AG | 127 (49.80) | 267 (50.28) | 1.06 (0.76-1.48) | 0.747 | 60 (50.85) | 127 (45.20) | 1.13 (0.72-1.79) | 0.595 | 187 (50.13) | 394 (48.52) | 1.10 (0.84-1.44) | 0.496 |
| AA | 45 (17.65) | 78 (14.69) | 1.28 (0.81-2.00) | 0.287 | 11 (9.32) | 39 (13.88) | 0.70 (0.33-1.48) | 0.351 | 56 (15.01) | 117 (14.41) | 1.11 (0.76-1.62) | 0.597 |
| Additive | 1.12 (0.90-1.39) | 0.324 | 0.92 (0.67-1.28) | 0.632 | 1.06 (0.89-1.27) | 0.510 | ||||||
| Dominant | 172 (67.45) | 345 (64.97) | 1.11 (0.81-1.52) | 0.533 | 71 (60.17) | 166 (59.07) | 1.03 (0.66-1.60) | 0.890 | 243 (65.15) | 511 (62.93) | 1.10 (0.85-1.42) | 0.465 |
| Recessive | 210 (82.35) | 453 (85.31) | 1.24 (0.83-1.85) | 0.302 | 107 (90.68) | 242 (86.12) | 0.65 (0.32-1.33) | 0.240 | 317 (84.99) | 695 (85.59) | 1.05 (0.74-1.48) | 0.784 |
| rs2979704 T>C (HWE=0.498 for combined subjects) | ||||||||||||
| TT | 83 (32.55) | 184 (34.65) | 1.00 | 48 (40.68) | 115 (40.93) | 1.00 | 131 (35.12) | 299 (36.82) | 1.00 | |||
| CT | 126 (49.41) | 268 (50.47) | 1.04 (0.74-1.45) | 0.835 | 60 (50.85) | 127 (45.20) | 1.11 (0.70-1.75) | 0.670 | 186 (49.87) | 395 (48.65) | 1.07 (0.82-1.41) | 0.602 |
| CC | 46 (18.04) | 79 (14.88) | 1.28 (0.82-2.00) | 0.286 | 10 (8.47) | 39 (13.88) | 0.62 (0.29-1.34) | 0.225 | 56 (15.01) | 118 (14.53) | 1.08 (0.74-1.58) | 0.680 |
| Additive | 1.11 (0.89-1.39) | 0.338 | 0.89 (0.64-1.23) | 0.465 | 1.05 (0.88-1.26) | 0.609 | ||||||
| Dominant | 172 (67.45) | 347 (65.35) | 1.09 (0.79-1.50) | 0.592 | 70 (59.32) | 166 (59.07) | 0.99 (0.64-1.54) | 0.968 | 242 (64.88) | 513 (63.18) | 1.08 (0.83-1.39) | 0.574 |
| Recessive | 209 (81.96) | 452 (85.12) | 1.25 (0.84-1.86) | 0.275 | 108 (91.53) | 242 (86.12) | 0.59 (0.28-1.22) | 0.155 | 317 (84.99) | 694 (85.47) | 1.04 (0.74-1.47) | 0.827 |
| rs1059111 A>T (HWE=0.535 for combined subjects) | ||||||||||||
| AA | 84 (32.94) | 185 (34.84) | 1.00 | 48 (40.68) | 115 (40.93) | 1.00 | 132 (35.39) | 300 (36.95) | 1.00 | |||
| AT | 122 (47.84) | 267 (50.28) | 1.00 (0.72-1.40) | 0.999 | 60 (50.85) | 127 (45.20) | 1.11 (0.70-1.75) | 0.670 | 182 (48.79) | 394 (48.52) | 1.05 (0.80-1.37) | 0.729 |
| TT | 49 (19.22) | 79 (14.88) | 1.35 (0.87-2.10) | 0.181 | 10 (8.47) | 39 (13.88) | 0.62 (0.29-1.34) | 0.225 | 59 (15.82) | 118 (14.53) | 1.14 (0.78-1.65) | 0.501 |
| Additive | 1.13 (0.91-1.41) | 0.256 | 0.89 (0.64-1.23) | 0.465 | 1.06 (0.89-1.27) | 0.506 | ||||||
| Dominant | 171 (67.06) | 346 (65.16) | 1.08 (0.79-1.48) | 0.634 | 70 (59.32) | 166 (59.07) | 0.99 (0.64-1.54) | 0.968 | 241 (64.61) | 512 (63.05) | 1.07 (0.83-1.38) | 0.608 |
| Recessive | 206 (80.78) | 452 (85.12) | 1.35 (0.91-2.00) | 0.134 | 108 (91.53) | 242 (86.12) | 0.59 (0.28-1.22) | 0.155 | 314 (84.18) | 694 (85.47) | 1.11 (0.79-1.55) | 0.560 |
OR, odds ratio; CI, confidence interval. a Adjusted for age and gender.