Table 2.
Stratification analysis for the association between NEFL gene polymorphisms and neuroblastoma susceptibility for combined subjects
| Variables | rs11994014 G>A | rs2979704 T>C | rs1059111 A>T | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| GG | AG/AA | Adjusted OR a | P a | TT | CT/CC | Adjusted OR a | P a | AA | AT/TT | Adjusted OR a | P a | |
| (Cases/Controls) | (95% CI) | (Cases/Controls) | (95% CI) | (Cases/Controls) | (95% CI) | |||||||
| Age, month | ||||||||||||
| ≤18 | 48/120 | 76/185 | 1.03 (0.67-1.58) | 0.903 | 48/117 | 76/188 | 0.99 (0.64-1.51) | 0.947 | 48/118 | 76/187 | 1.00 (0.65-1.53) | 0.997 |
| >18 | 82/181 | 167/326 | 1.13 (0.82-1.56) | 0.451 | 83/182 | 166/325 | 1.12 (0.81-1.54) | 0.487 | 84/182 | 165/325 | 1.10 (0.80-1.51) | 0.559 |
| Gender | ||||||||||||
| Females | 50/135 | 107/207 | 1.40 (0.94-2.09) | 0.099 | 50/131 | 107/211 | 1.33 (0.89-1.99) | 0.161 | 50/132 | 107/210 | 1.35 (0.90-2.01) | 0.143 |
| Males | 80/166 | 136/304 | 0.93 (0.66-1.30) | 0.662 | 81/168 | 135/302 | 0.93 (0.66-1.30) | 0.657 | 82/168 | 134/302 | 0.91 (0.65-1.27) | 0.574 |
| Sites of origin | ||||||||||||
| Adrenal gland | 49/301 | 85/511 | 1.02 (0.70-1.49) | 0.918 | 50/299 | 84/513 | 0.98 (0.67-1.43) | 0.918 | 50/300 | 84/512 | 0.98 (0.67-1.44) | 0.933 |
| Retroperitoneal | 24/301 | 63/511 | 1.53 (0.93-2.50) | 0.092 | 24/299 | 63/513 | 1.52 (0.93-2.48) | 0.098 | 25/300 | 62/512 | 1.44 (0.89-2.34) | 0.142 |
| Mediastinum | 39/301 | 70/511 | 1.07 (0.70-1.62) | 0.764 | 39/299 | 70/513 | 1.05 (0.69-1.59) | 0.822 | 39/300 | 70/512 | 1.06 (0.70-1.60) | 0.797 |
| Others | 14/301 | 21/511 | 0.88 (0.44-1.76) | 0.719 | 14/299 | 21/513 | 0.87 (0.44-1.74) | 0.696 | 14/300 | 21/512 | 0.88 (0.44-1.75) | 0.709 |
| Clinical stages | ||||||||||||
| I+II+4s | 53/301 | 111/511 | 1.25 (0.87-1.78) | 0.230 | 55/299 | 109/513 | 1.16 (0.81-1.65) | 0.412 | 55/300 | 109/512 | 1.17 (0.82-1.66) | 0.392 |
| III+IV | 70/301 | 119/511 | 1.01 (0.72-1.40) | 0.978 | 70/299 | 119/513 | 1.00 (0.72-1.39) | 0.985 | 70/300 | 119/512 | 1.00 (0.72-1.39) | 0.998 |
OR, odds ratio; CI, confidence interval. a Adjusted for age and gender, omitting the corresponding stratification factor.