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STING does not contribute to antipneumococcal defense in mice. WT and STING-deficient mice were intranasally infected with 5 × 106 CFU (A to C) or 5 × 105 CFU (D to F) S. pneumoniae, and the bacterial burdens in the lungs (A and D), spleen (B and E), and blood (C and F) were measured 48 h postinfection. Data represent means ± SD from 7 or 8 mice per group. Comparisons were performed with the Mann-Whitney U test.
