Table 4.

Markers of coagulation and fibrinolysis before and after 2 months of vitamin D suppletion.

Parameter	At time of inclusion – median (IQR)	After 2 months of suppletion – median (IQR)	P valuea
Coagulation
PT (s)
VIDD with SHPT	11.6 (10.9–12.1)	11.7 (10.9–12.1)	0.93
VIDD	11.5 (11.0–12.1)	11.6 (11.1–12.1)	0.90
Controls	11.6 (11.1–12.0)	11.6 (11.2–11.9)	0.21
aPTT (s)
VIDD with SHPT	32.0 (29.6–33.7)	31.2 (29.0–33.7)	0.07
VIDD	31.9 (30.2–34.4)	31.9 (29.6–33.7)	0.06
Controls	32.3 (29.4–33.7)	31.6 (29.5–33.2)	0.06
Fibrinogen (g/L)
VIDD with SHPT	3.4 (2.9–4.0)	3.3 (2.9–4.1)	0.49
VIDD	3.4 (2.8–4.0)	3.4 (2.9–4.1)	0.18
Controls	3.5 (3.1–4.0)	3.5 (2.9–4.0)	0.72
VWF (%)
VIDD with SHPT	117 (101–158)	121 (95–184)	0.14
VIDD	125 (103–162)	127 (105–176)	0.21
Controls	117 (88–143)	115 (89–144)	0.85
FVII (%)
VIDD with SHPT	108 (86–142)	104 (88–138)	0.81
VIDD	114 (87–140)	112 (88–136)	0.52
Controls	124 (103–143)	130 (109–152)	0.41
FVIII (%)
VIDD with SHPT	144 (130–182)	154 (128–185)	0.47
VIDD	145 (130–175)	151 (130–181)	0.81
Controls	139 (108–159)	145 (112–159)	0.10
FX (%)
VIDD with SHPT	92 (77–114)	96 (80–119)	0.02
VIDD	98 (82–114)	100 (87–119)	0.10
Controls	99 (84–116)	99 (87–114)	0.26
Thrombin generation
Lag time (min)
VIDD with SHPT	5.0 (4.3–5.6)	4.6 (4.2–5.7)	0.74
VIDD	5.1 (4.5–5.8)	5.0 (4.3–5.7)	0.44
Controls	4.9 (4.5–5.6)	5.0 (4.3–5.7)	0.25
Peak (%)
VIDD with SHPT	121 (92–164)	125 (98–161)	0.81
VIDD	120 (93–163)	128 (98–162)	0.17
Controls	120 (104–185)	128 (110–166)	0.55
ETP (%)
VIDD with SHPT	105 (92–128)	105 (93–123)	0.96
VIDD	106 (92–130)	112 (94–127)	0.70
Controls	106 (94–138)	111 (95–131)	0.47
Fibrinolysis
d-dimer (mg/L)
VIDD with SHPT	0.34 (0.24–0.50)	0.37 (0.23–0.52)	0.79
VIDD	0.33 (0.22–0.50)	0.34 (0.23–0.52)	0.82
Controls	0.31 (0.18–0.56)	0.30 (0.20–0.55)	0.78
TAFI
VIDD with SHPT	85 (78–93)	84 (76–96)	0.88
VIDD	85 (76–93)	84 (75–95)	0.88
Controls	90 (81–100)	91 (81–99)	0.71
n-CLT (%)
VIDD with SHPT	89 (76–109)	91 (79–106)	0.41
VIDD	96 (81–116)	94 (84–109)	0.57
Controls	89 (80–100)	93 (81–103)	0.35

Data are expressed as median (interquartile range). P-values < 0.05 are in bold. P values were rounded to 2 decimals. Null hypothesis: there are no statistically significant differences between the time of inclusion and after two months of vitamin D suppletion.

^aWilcoxon signed rank test.

IQR, interquartile range; PT, prothrombin time; VIDD, vitamin D deficiency; SHPT, secondary hyperparathyroidism; aPTT, activated partial thromboplastin time; VWF, Von Willebrand Factor; F, factor; ETP, endogenous thrombin potential; TAFI, thrombin-activatable fibrinolysis-inhibitor; n-CLT, normalized clot lysis time.