Figure 4.

Topographic structures of ${\overline{\Phi }}_R$ and EEG connectivity of the alpha band across states of consciousness in the two anesthetic experiments of (A) ketamine, and (B) propofol followed by isoflurane. The first and second row in (A,B) present the topography structure of ${\overline{\Phi }}_R$ and node degree of 96 EEG channels, respectively, which is averaged over all subjects across states. The topographical structures and the overall strengths represent various states of consciousness. For example, higher ${\overline{\Phi }}_R$ and node degree of the posterior region in the baseline state is disrupted in the anesthetized state and restored partly with recovery of responsiveness. The scales of ${\overline{\Phi }}_R$ and node degree topographies are the same among the states in each experiment, but different between the two experiments. The topographies of node degree and ${\overline{\Phi }}_R$ for the other frequency bands are presented in Supplementary Figure 4.